Why So Many People Stop Taking GLP1s – What Clients Should Know
Injection pen for a generic semaglutide medication.
GLP1 medications like Ozempic, Wegovy, and Mounjaro have become widely known for their potential to support weight loss and blood sugar regulation.
But for many people, these medications are not a long-term solution. Research shows that between 50–75% of GLP1 users stop within the first year—often due to side effects, cost, or limited access.
Why People Stop GLP1s
While GLP1s can be effective for some people, they come with challenges that many users don’t anticipate. Common reasons for discontinuation include nausea, fatigue, and digestive discomfort. Others find that the medication is no longer covered by insurance, or that the out-of-pocket costs become unsustainable.
In addition, about 10–16% of people are considered “non-responders”—meaning their body simply doesn’t respond to the medication as hoped. For these individuals, even after months of use, there may be little to no weight loss. But then in some situations, some “super responders” experience rapid or significant loss, which can set unrealistic expectations for others and lead to disappointment when results vary.
The Emotional Impact
When the medication doesn’t work as expected, or when someone has to stop for reasons beyond their control, the emotional toll can be significant.
Clients may describe feelings of frustration, shame, or failure, even though the outcome has nothing to do with personal effort or willpower. [link to the second blog on mental health]
There are also growing concerns about mental health symptoms linked to GLP1 use, including increased anxiety, depression, and even suicidal ideation. While more research is needed, these risks [link to the third blog on risks] are important for clients and providers to discuss before and during treatment, and unfortunately some patients feel they are not adequately educated on the risks.
Compounded Versions
Another challenge comes from the rise of compounded GLP1s, which are not FDA-approved. These versions can vary in quality, dosage, and storage, raising questions about safety and effectiveness. For some users, side effects or complications may stem from these unregulated sources rather than the medication itself.
What Happens After Stopping
For most people who discontinue GLP1s, weight regain is common. Studies suggest that up to 90% regain most or all of the weight they lost. Appetite and cravings may also intensify, leaving clients feeling out of control or discouraged.
Understanding that these reactions are biological, not moral failings, is important. The body naturally seeks to restore its set point after rapid weight loss. Without ongoing support, both physically and emotionally, many people struggle in the transition off medication.
If you’ve stopped taking a GLP1 or are thinking about it, you’re not alone. This transition can bring up complex thoughts and feelings around food, body image, and control. With compassionate, eating disorder–informed support, it’s possible to navigate these changes with care and understanding. I provide therapy across Massachusetts, Rhode Island, Vermont, and New Hampshire, please reach out.
